All munchkin sets can be played with each other but expansions work best with the main/deluxe sets they are related to.
More of the twisted humor of Steve Jackson and John Kovalic in a 112-card supplement for Munchkin!
De-Ranged has everything you love about Munchkin, including:
A new Class! Rangers can tame monsters and ride them! Treasure! Track down the Philosopher's Scone, put Racing Stripes on your Steed, and fill your Canteen of Spleen with Carbonated Holy Water! Monsters! Beware the Telemarketer, the Poultrygeist, and the Undead Clowns. And more monsters: imports! That's right, unique monsters created by the European Munchkin publishers, available for the first time in English. Quake in fear at the Brothers Grimm and the Snerks! Or just kill them and take their stuff. Your choice.
Munchkin 5 -- De-Ranged. All the munchkin-ism of a prestige class, with none of that annoying roleplaying stuff.